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Updated: Jun 21, 2026
A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)
Published on: March 7, 2017
Pediatric high-grade gliomas and diffuse intrinsic pontine gliomas
1Department of Hematology/Oncology/Stem Cell Transplantation, Children's Memorial Hospital, Chicago, IL 60614, USA. jfangusaro@childrensmemorial.org
Abstract:
Pediatric high-grade gliomas represent approximately 10% of all pediatric brain tumors. Similar to adult high-grade gliomas, they behave very aggressively, and these children have a very poor prognosis despite a variety of therapies that include chemotherapy and radiotherapy. In this review, we present an overview of both pediatric high-grade gliomas and diffuse intrinsic pontine gliomas with a focus on their epidemiology, etiology, presentation, prognostic factors, biology, treatment modalities, outcomes, and future research directions.
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