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Clinico-serological profile of juvenile idiopathic arthritis

Madhumita Nandi1, Suhas K Ganguli, Rakesh Mondal

  • 1Department of Pediatrics, Institute of Post Graduate Medical Education and Research and SSKM Hospital, Kolkata, India. madhumitabanik@rediffmail.com

Indian Pediatrics
|July 30, 2009
PubMed

Insights

This study details the clinical and serological features of 210 children diagnosed with Juvenile idiopathic arthritis (JIA). Key findings highlight common disease patterns and joint involvement in pediatric arthritis patients.

Area of Science:

  • Pediatric Rheumatology
  • Immunology
  • Clinical Medicine

Background:

  • Juvenile idiopathic arthritis (JIA) is a heterogeneous autoimmune disease affecting children.
  • Understanding the clinico-serological profile is crucial for accurate diagnosis and management.
  • ILAR classification criteria provide a standardized approach to JIA diagnosis.

Purpose of the Study:

  • To describe the clinico-serological profile of 210 children diagnosed with Juvenile idiopathic arthritis (JIA).
  • To analyze the distribution of JIA subtypes and identify frequently affected joints.
  • To report the prevalence of Antinuclear factor (ANF) and Rheumatoid factor (RF) positivity across different JIA subtypes.

Main Methods:

  • Retrospective analysis of clinical and laboratory data from 210 pediatric patients with JIA.
  • Diagnosis confirmed using the International League of Associations for Rheumatology (ILAR) classification criteria.
  • Assessment of joint involvement and serological markers including ANF and RF.

Main Results:

  • Polyarticular, oligoarticular, and systemic onset JIA were observed in 72, 69, and 40 children, respectively.
  • The knee joint was the most commonly affected joint across all JIA subtypes.
  • ANF positivity ranged from 7-10%, and RF positivity from 7-20% across the different JIA subtypes.

Conclusions:

  • The study provides a comprehensive clinico-serological profile of JIA in a pediatric cohort.
  • Findings underscore the importance of joint assessment and serological markers in characterizing JIA subtypes.
  • This data can aid in refining diagnostic and therapeutic strategies for pediatric arthritis.

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