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Profile of viral hepatitis A in Chennai

Shrishu R Kamath1, Malathi Sathiyasekaran, T Eswara Raja

  • 1Mehta Children Hospital, Chennai, India.

Indian Pediatrics
|July 30, 2009
PubMed

Insights

Hepatitis A virus infection in children shows older kids have more atypical symptoms like ascites and splenomegaly. This study analyzed 138 pediatric cases of acute hepatitis A.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Hepatology

Background:

  • Acute viral hepatitis A is a common infection in children.
  • Understanding age-related clinical presentations is crucial for timely diagnosis and management.

Purpose of the Study:

  • To compare clinical features, laboratory findings, and complications of hepatitis A virus (HAV) infection across different pediatric age groups.
  • To identify age-specific patterns in the presentation of acute hepatitis A.

Main Methods:

  • Retrospective analysis of 138 children diagnosed with anti-HAV IgM positive acute viral hepatitis A.
  • Data collected included clinical manifestations, laboratory results, and recorded complications.
  • Children were stratified into three age groups: 1-5 years, 5-10 years, and 10-15 years.

Main Results:

  • Older children (10-15 years) exhibited more atypical manifestations of HAV infection compared to younger groups.
  • Ascites and splenomegaly were more frequently observed in older children.
  • The study identified significant differences in clinical presentation based on age.

Conclusions:

  • Age is a significant factor influencing the clinical presentation and complications of hepatitis A virus infection in children.
  • Pediatricians should consider atypical presentations, such as ascites and splenomegaly, in older children with suspected hepatitis A.
  • Further research may elucidate the underlying mechanisms for these age-related differences.

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