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Published on: February 12, 2022
[CD4-positive diffuse large B-cell lymphoma]
Tomonori Nakazato1, Kazuhito Suzuki, Ai Mihara
1Department of Hematology/Oncology, Yokohama Municipal Citizen's Hospital.
Summary
This study reports the first case of CD4-positive diffuse large B-cell lymphoma (DLBCL) in an 82-year-old man. The patient achieved complete remission after R-CHOP treatment for this rare DLBCL subtype.
Area of Science:
- Hematology
- Oncology
- Immunophenotyping
Background:
- Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
- Accurate diagnosis relies on detailed immunophenotypic analysis.
- CD4 positivity is an unusual finding in DLBCL.
Observation:
- An 82-year-old male presented with lymphadenopathy after lung cancer surgery.
- Biopsy revealed diffuse large B-cell lymphoma.
- Immunophenotyping showed CD4 and CD19 co-expression on lymphoma cells.
Findings:
- The patient was diagnosed with a rare CD4-positive DLBCL.
- Treatment with R-CHOP resulted in complete remission.
- This represents the first reported case of CD4-positive DLBCL.
Implications:
- Highlights the importance of comprehensive immunophenotyping for DLBCL subtyping.
- Suggests CD4-positive DLBCL may be a distinct entity.
- Further research is needed to understand the biology and optimal treatment of this rare subtype.
