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Demonstration of clonality in T-cell lymphoma using an anti-T-cell receptor variable region antibody panel
J O'Grady1, A S Krajewski, E F Ramage
1Department of Pathology, University Medical School, Edinburgh, Scotland, UK.
Histopathology
|December 1, 1990
Abstract:
Frozen sections from 35 T-cell lymphomas were stained with the Diversi-T alpha beta T-Cell Receptor panel which includes seven antibodies to T-cell receptor variable region gene products. In five cases a monoclonal population of T-cells could be demonstrated (one case V beta 5+, three cases V beta 8+ and one case V beta 6+) and in a further case a biclonal population (V beta 5+ and V beta 8+). We conclude that this antibody panel is of limited usefulness for the demonstration of clonality in T-cell lymphoma.