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Published on: February 21, 2018
Diagnostic test validation: cochlear hydrops analysis masking procedure in Ménière's disease
Leonardo Elías Ordóñez-Ordóñez1, Eveling Rojas-Roncancio, Víctor Hernández-Alarcón
1Universidad Militar Nueva Granada, Otolaryngology Department, Hospital Universitario Clínica San Rafael, Bogotá, Colombia. otoleor@gmail.com
Objective:
To determine the diagnostic value of the cochlear hydrops analysis masking procedure (CHAMP) in patients with definite Ménière's disease.
Study Design:
Prospective validation study for a diagnostic test, study phase 2.
Setting:
Tertiary referral centers.
Patients:
Subjects with definite Ménière's disease (Group 1), differential diagnosis (Group 2: another audiovestibular diseases or neurologic disorders), and normal hearing (Group 3) were included. Sample sizes were calculated.
Interventions:
Study test (CHAMP) was compared with the current clinical criterion standard described by the guidelines of the American Academy of Otolaryngology-Head and Neck Surgery.
Main Outcome Measure:
Sensitivity, specificity, and other indicators of diagnostic validation.
Results:
One hundred ten cases completed the follow-up, and their results are presented. Sensitivity at 31.3% and specificity at 100% were found in subjects with definite Ménière's disease, features that are more helpful in confirming the diagnosis than in rejecting it. Group 1 showed significantly shorter latency delays than Groups 2 and 3 (p < 0.001).
Conclusion:
If definite Ménière's disease is suspected, an abnormal result confirms the diagnosis; however, a normal result does not rule out the Ménière's disease diagnosis.
