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Signal recognition particle (SRP) positive myositis in a patient with cryptogenic organizing pneumonia (COP)

Felix Wantke1, Meinhard Kneussl, Marianne Hubner

  • 1Department of Pneumonology, Medical University of Vienna, Wilhelminenspital, Vienna, Austria. felix.wantke@wienkav.at

Rheumatology International
|July 30, 2009
PubMed

Insights

A rare case of anti-SRP necrotizing myositis, following organizing pneumonia, showed complete recovery using extracorporeal treatment. This plasma exchange and immunoadsorption therapy led to undetectable antibody levels within 33 months.

Area of Science:

  • Rheumatology
  • Immunology
  • Neurology

Background:

  • Anti-signal recognition particle (anti-SRP) necrotizing myositis is a rare autoimmune condition.
  • Organizing pneumonia can precede or co-occur with myositis.

Observation:

  • A 46-year-old female presented with organizing pneumonia followed by anti-SRP necrotizing myositis.
  • The patient had no cardiac involvement or dysphagia.
  • Myositis symptoms showed full regression.

Findings:

  • Extracorporeal treatment, specifically combined plasma exchange and immunoadsorption, was effective.
  • Oral immunosuppression was not required for treatment.
  • Anti-SRP antibodies became undetectable after 33 months of therapy.

Implications:

  • This case highlights the efficacy of extracorporeal treatment for anti-SRP myositis.
  • It suggests a potential treatment alternative to oral immunosuppression.
  • Successful antibody clearance indicates a favorable long-term prognosis.

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