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Updated: Jun 21, 2026
A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
Melanoma of unknown origin: a case series
1Department of Academic Surgery, Cork University Hospital, Cork, Ireland. justinjoshkelly@gmail.com
Introduction:
The natural history of metastatic melanoma involving lymph nodes, in the absence of a known primary site (cutaneous, ocular or mucosal) has, to date, been poorly defined; and the optimal management of this rare subtype of disease is therefore unclear. Melanomas of unknown primary site (MUP) are estimated to comprise between 3.7 and 6% of all melanomas (Anbari et al. in Cancer 79:1861-1821, 1997).
Materials And Methods:
Between 2002 and 2007, 478 patients were treated for melanoma in our department in Cork University Hospital, five of whom presented with MUP. We discuss their cases herein.
Conclusion:
We should continue to treat this cohort of patients with an aggressive surgical approach and consider them for adjuvant therapies currently used to treat stage III disease.
