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Updated: Jun 21, 2026

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
Published on: September 26, 2025
[Study on vitro release and transdermal behaviors of Yulian cataplasm]
Maobo Du1, Shuzhi Liu, Manling Li
1Institute of Chinese Materia Medica China Academy of Chinese Medical Science, Beijing 100700, China.
Objective:
To investigate the regularity of Yulian Cataplasm in vitro release and transdermal behaviors.
Method:
Improved Franz diffusion devices was used with four index ingredients as evodiamine, rutaecarpine, palmatine and berberine that were determined by HPLC in one mobile phase.
Result:
The release rates of evodiamine, rutaecarpine, palmatine and berberine were 0.0239, 0.0156, 0.0725, 0.8191 mg x cm(-2) x h(-1/2), respectivley. The transdermal rates of evodiamine, rutaecarpine, palmatine and berberine were 1.256, 1.0302, 2.8029, 20.919 microg x cm(-2) x h(-1), respectively.
Conclusion:
The releasing process of all index is in accordance with Higuchi equation and the transdermal proccess is in accordance with zero-level equation.
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