Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 21, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Adjuvant approaches to enhance cryosurgery.

Raghav Goel1, Kyle Anderson, Joel Slaton

  • 1Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.

Journal of Biomechanical Engineering
|July 31, 2009
PubMed
Summary

Molecular adjuvants enhance cryosurgery by increasing cancer cell destruction and reducing damage to healthy tissue. This review explores various adjuvants, including TNF-alpha, for improved cryosurgical outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rate of decline in residual kidney function and cognitive impairment in incident haemodialysis patients: A prospective, longitudinal analysis of the BISTRO trial cohort.

PloS one·2026
Same author

A guide to cryogenic refrigerant properties and selection for tissue & organ cryopreservation.

Cryobiology·2026
Same author

Cryopreservation and other preservation approaches for animal models workshop session I: Invertebrate models in biomedical research.

Cryobiology·2026
Same author

Clinical-grade cryopreservation unlocks transplant-ready human pancreatic and stem cell-derived islets for diabetes therapy.

bioRxiv : the preprint server for biology·2026
Same author

Inducing radiation resilience in frozen animal cells via mRNA coding for tardigrade damage-suppressor protein in support of space travel and Lunar storage.

The Journal of heredity·2026
Same author

In vivo toxicity assessment of silica-coated iron oxide nanoparticles for nanowarming in organ cryopreservation.

Journal of nanobiotechnology·2026

Area of Science:

  • Oncology
  • Surgical Innovation
  • Biomedical Engineering

Background:

  • Cryosurgery utilizes freezing to destroy diseased tissue.
  • Adjuvants can enhance cryosurgical efficacy and safety.
  • Current cryosurgery faces challenges in local disease control and normal tissue preservation.

Purpose of the Study:

  • To review the use of molecular adjuvants in cryosurgery.
  • To explore mechanisms by which adjuvants improve cryosurgical outcomes.
  • To highlight promising adjuvants for enhanced cryosurgical treatments.

Main Methods:

  • Overview of cryosurgical technology and injury mechanisms.
  • Discussion of four classes of molecular adjuvants: thermophysical, chemotherapeutic, vascular, and immunomodulatory agents.

More Related Videos

Thermal Ablation for the Treatment of Abdominal Tumors
07:16

Thermal Ablation for the Treatment of Abdominal Tumors

Published on: March 7, 2011

Related Experiment Videos

Last Updated: Jun 21, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Thermal Ablation for the Treatment of Abdominal Tumors
07:16

Thermal Ablation for the Treatment of Abdominal Tumors

Published on: March 7, 2011

  • Analysis of adjuvant selection, timing, dose, and delivery.

    • Main Results:

    • Adjuvants increase tissue sensitivity to freeze-thaw injury.
    • Thermophysical agents, chemotherapeutics, vascular agents, and immunomodulators offer distinct benefits.
    • Tumor necrosis factor-alpha (TNF-alpha) shows potential for complete cancer destruction within the cryosurgical iceball.

    Conclusions:

    • Molecular adjuvants represent a significant advancement in cryosurgery.
    • Combinatorial approaches enhance local disease control and minimize collateral damage.
    • Targeted adjuvant use, particularly vascular agents like TNF-alpha, promises improved therapeutic results in cryosurgery.