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An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage

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Strain-dependent oxygen diffusivity in bovine annulus fibrosus.

T-Y Yuan¹, A R Jackson, C-Y Huang

¹Department of Biomedical Engineering, Tissue Biomechanics Laboratory, University of Miami, Coral Gables, FL 33146, USA.

Journal of Biomechanical Engineering

|July 31, 2009

Summary

Mechanical loading significantly reduces oxygen transport in intervertebral disc (IVD) tissue. This study quanties oxygen diffusivity in bovine annulus fibrosus (AF) under varying compressive strains, revealing decreased oxygen diffusion with increased strain.

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Area of Science:

Biomedical Engineering
Tissue Mechanics
Biophysics

Background:

The intervertebral disc (IVD) is the body's largest avascular structure, relying on diffusion for nutrient transport.
Oxygen supply to the IVD is crucial for its health and function, yet the impact of mechanical loading on this process remains understudied.

Purpose of the Study:

To investigate the strain-dependent behavior of oxygen diffusivity within intervertebral disc (IVD) tissue.
To quantify the effect of mechanical compression on oxygen transport in the annulus fibrosus (AF).

Main Methods:

A one-dimensional steady-state diffusion experiment was conducted using bovine coccygeal annulus fibrosus (AF) specimens.
Oxygen diffusivity was measured under three distinct levels of compressive strain (approximately 5%, 14%, and 24%).
Calculations were based on Fick's law of diffusion.

Main Results:

Oxygen diffusivity in bovine AF decreased significantly with increasing compressive strain.
At 4.68% strain, diffusivity was 1.43x10^-5 cm²/s; at 14.2% strain, it was 1.05x10^-5 cm²/s; and at 23.7% strain, it was 7.71x10^-6 cm²/s.
A statistically significant reduction (p<0.05) in oxygen diffusivity was observed as strain levels increased.

Conclusions:

Mechanical loading has a significant, detrimental effect on oxygen transport in IVD tissues.
Understanding these strain-dependent changes in oxygen diffusivity is vital for comprehending IVD health and degeneration processes.
This research provides critical data on oxygen transport mechanisms within the annulus fibrosus.