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Paradigms for Pharmacological Characterization of C. elegans Synaptic Transmission Mutants

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Published on: August 18, 2008

Avermectin intoxication with coma, myoclonus, and polyneuropathy.

Yueh-Feng Sung¹, Chuang-Ti Huang, Cheng-Kuo Fan

¹Department of Neurology, Tri-Service General Hospital, Taipei, Taiwan, Republic of China. sungyf@ndmctsgh.edu.tw

Clinical Toxicology (Philadelphia, Pa.)

|July 31, 2009

Summary

This case report details severe avermectin poisoning in a human, presenting with coma, myoclonus, and polyneuropathy after a massive oral dose. These symptoms highlight avermectin

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Area of Science:

Toxicology
Neuroscience
Pharmacology

Background:

Avermectin is widely used for parasite and insect control.
Severe avermectin poisoning in humans can manifest as altered mental status, hypotension, and respiratory failure.

Observation:

A case of acute avermectin intoxication following a very high oral dose (414.2 mg/kg) is presented.
The patient exhibited coma, myoclonus, and polyneuropathy.

Findings:

The observed symptoms, including myoclonus and polyneuropathy, are directly linked to avermectin poisoning.
Potential contribution of solvents or additives to the toxicity is also considered.

Implications:

This report documents the first known case of avermectin poisoning associated with myoclonus and polyneuropathy.
Highlights the critical need for prompt medical intervention in severe avermectin intoxication cases.