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Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
06:29

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

Clinical evaluation of magnetic resonance imaging in coronary heart disease: the CE-MARC study

John P Greenwood1, Neil Maredia, Aleksandra Radjenovic

  • 1Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds General Infirmary, Leeds, LS1 3EX, UK. j.greenwood@leeds.ac.uk

Trials
|July 31, 2009
PubMed

Insights

This study prospectively evaluates cardiovascular magnetic resonance (CMR) for diagnosing coronary heart disease (CHD) in 750 patients. It compares CMR

Area of Science:

  • Cardiovascular Imaging
  • Diagnostic Accuracy Studies
  • Cardiac Magnetic Resonance

Background:

  • Coronary heart disease (CHD) diagnosis relies on multiple tests.
  • Cardiovascular magnetic resonance (CMR) provides comprehensive data in a single session.
  • Large-scale prospective data on multi-parametric CMR for CHD detection are limited.

Purpose of the Study:

  • To determine the diagnostic accuracy of multi-parametric CMR for detecting significant coronary stenosis.
  • To compare CMR's performance against exercise tolerance testing (ETT) and single photon emission tomography (SPECT).
  • To assess the prognostic value and cost-effectiveness of CMR in suspected CHD patients.

Main Methods:

  • Prospective diagnostic accuracy cohort study of 750 patients with suspected CHD.
  • Patients underwent CMR, SPECT, and invasive X-ray coronary angiography (reference standard).
  • CMR protocol included rest/stress perfusion, cine, late gadolinium enhancement, and MR coronary angiography.

Main Results:

  • The study aimed to establish the diagnostic accuracy of CMR for significant coronary stenosis.
  • Secondary analyses focused on prognostic value, cost-effectiveness, and comparison with ETT and SPECT.
  • Results will provide crucial data on CMR's role in unselected populations.

Conclusions:

  • The CE-MARC study is a key trial assessing multi-parametric CMR for CHD diagnosis.
  • It utilizes invasive coronary angiography as the gold standard for comparison.
  • Findings will inform clinical practice regarding CMR's utility and comparative effectiveness.
Abstract

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