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Related Experiment Video

Updated: Jun 21, 2026

Live Cell Imaging of Chromosome Segregation During Mitosis

Live Cell Imaging of Chromosome Segregation During Mitosis

Published on: March 14, 2018

Cell division: righting the check.

Brian G Fuller¹, P Todd Stukenberg

¹Department of Biochemistry and Molecular Genetics, University of Virginia Medial School, Charlottesville, VA 22901, USA. bgf4b@virginia.edu

Current Biology : CB

|July 31, 2009

Summary

This summary is machine-generated.

Two new studies in yeast reveal how the spindle checkpoint is silenced, a crucial final step in cell division. This research advances our understanding of mitosis and cell cycle regulation.

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Last Updated: Jun 21, 2026

Live Cell Imaging of Chromosome Segregation During Mitosis

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Published on: March 14, 2018

Mammalian Cell Division in 3D Matrices via Quantitative Confocal Reflection Microscopy

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Published on: November 29, 2017

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

Area of Science:

Cell Biology
Molecular Biology
Genetics

Background:

Yeast models, including fission and budding yeast, are vital for dissecting fundamental cellular processes.
Cell division, particularly mitosis, involves complex regulatory pathways.
The spindle checkpoint is a critical surveillance mechanism ensuring proper chromosome segregation.

Purpose of the Study:

To investigate the mechanisms underlying the silencing of the spindle checkpoint.
To elucidate the final steps of mitosis in yeast models.
To provide new insights into cell cycle regulation.

Main Methods:

Comparative analysis of fission yeast (Schizosaccharomyces pombe) and budding yeast (Saccharomyces cerevisiae).
Genetic and molecular approaches to study cell division pathways.
Microscopy and biochemical assays to observe and analyze mitotic events.

Main Results:

Identification of key factors and pathways involved in spindle checkpoint silencing in both yeast species.
Demonstration of conserved and divergent mechanisms across different yeast models.
Detailed characterization of the temporal and spatial regulation of checkpoint silencing.

Conclusions:

The studies offer a comprehensive view of spindle checkpoint silencing, a critical event terminating mitosis.
Findings in yeast provide a foundation for understanding similar processes in higher eukaryotes.
This research opens new avenues for exploring cell cycle control and its dysregulation.