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Fragmented coronoid process in the dog: a heritable disease.

Jedee Temwichitr¹, Peter A J Leegwater, Herman A W Hazewinkel

¹Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, P.O. Box 80154, 3508 TD Utrecht, The Netherlands.

Veterinary Journal (London, England : 1997)

|July 31, 2009

Summary

Fragmented coronoid process (FCP) in dogs causes elbow joint osteoarthritis. Identifying the specific genes responsible for this hereditary condition is crucial for developing effective treatments and preventative strategies.

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Area of Science:

Veterinary Orthopedics
Canine Genetics
Elbow Dysplasia Research

Background:

Fragmented coronoid process (FCP) is a primary component of canine elbow dysplasia.
It commonly affects medium-to-large dog breeds, leading to front leg lameness and osteoarthrosis.
Current treatments do not prevent joint degeneration.

Purpose of the Study:

To provide a comprehensive overview of fragmented coronoid process (FCP).
To explore elbow joint development and disease pathogenesis hypotheses.
To discuss the genetic basis of FCP and methods for gene identification.

Main Methods:

Literature review on elbow joint development and FCP pathogenesis.
Analysis of existing knowledge regarding the genetic background of FCP.
Overview of genetic methodologies applicable to identifying FCP-associated genes.

Main Results:

FCP is a significant cause of canine elbow joint disease.
Osteoarthrosis is a common outcome in affected dogs.
The genetic factors underlying FCP remain largely unidentified.

Conclusions:

Understanding FCP pathogenesis and genetics is vital for canine health.
Further research is needed to identify the specific genes responsible for FCP.
Genetic insights could lead to improved diagnostics and targeted therapies for elbow dysplasia.