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Articles linked to this work by shared authors, journal, and citation graph.

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Day-care for breast cancer: ambulatory surgery and intra-operative radiation. Techniques and preliminary results of the Centre Val-d'Aurelle--Montpellier.

Journal of visceral surgery·2014
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Clinical and technical characteristics of intraoperative radiotherapy. Analysis of the ISIORT-Europe database.

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Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
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[Intraoperative radiotherapy: back to the future?].

J-B Dubois1

  • 1Département d'oncologie radiothérapie, CRLC Val-d'Aurelle - 34298 Montpellier cedex 5, France. Jean-Bernard.Dubois@valdorel.fnclcc.fr

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|July 31, 2009
PubMed
Summary

Intraoperative radiotherapy (IORT) uses electrons to target tumors during surgery, optimizing the dose for better tumor control and reduced healthy tissue exposure. This technique is effective for various cancers, including recurrences and partial breast irradiation.

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Area of Science:

  • Oncology
  • Radiotherapy
  • Surgical Oncology

Context:

  • Intraoperative radiotherapy (IORT) has evolved since its early Japanese publications, utilizing electron beams with homogeneous techniques.
  • It is applied across diverse clinical indications, aiming to enhance the therapeutic ratio by concentrating radiation dose within a limited tumor volume.

Purpose:

  • To investigate the efficacy and application of intraoperative radiotherapy (IORT) in managing various malignancies.
  • To evaluate IORT as a boost or exclusive treatment delivered in a single fraction during surgical procedures.

Summary:

  • IORT involves delivering a high dose of radiation directly to the tumor site during surgery, minimizing exposure to surrounding healthy tissues.
  • Key indications include recurrences of digestive and gynecological tumors, retroperitoneal sarcomas, and partial breast irradiation for early-stage breast cancer in elderly patients.
  • The technique aims to improve treatment outcomes by optimizing the dose delivered to the tumor while sparing adjacent critical structures.

Impact:

  • IORT offers an optimized therapeutic ratio, potentially improving tumor control rates and reducing treatment-related toxicity.
  • Its application in breast-conserving surgery, particularly for elderly patients with small tumors, highlights its versatility.
  • The technique represents an advancement in localized cancer treatment strategies, integrating radiation therapy directly into the surgical workflow.