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Updated: Jun 21, 2026

Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis
Published on: August 15, 2025
Sulfated xylomannans from the red seaweed Sebdenia polydactyla: structural features, chemical modification and
Tuhin Ghosh1, Carlos Alberto Pujol, Elsa Beatriz Damonte
1Natural Products Laboratory, Department of Chemistry, University of Burdwan, West Bengal, India.
Background:
Many viruses display affinity for cell surface heparan sulfate proteoglycans with biological relevance in virus entry. This raises the possibility of the application of sulfated polysaccharides in antiviral therapy.
Methods:
In this study, we analysed polysaccharide fractions isolated from Sebdenia polydactyla.
Results:
The purified xylomannan sulfate and its further sulfated derivatives showed strong activity against herpes simplex virus type-1 (HSV-1). Their 50% inhibitory concentration values were in the range 0.35-2.8 microg/ml and they lacked cytotoxicity at concentrations up to 1,000 microg/ml. The major polysaccharide, which had 0.6 sulfate groups per monomer unit and an apparent molecular mass of 150 kDa, contained a backbone of alpha-(1-->3)-linked d-mannopyranosyl residues substituted at position 6 with a single stub of beta-d-xylopyranosyl residues.
Conclusions:
The degree of sulfation seemed to play an important role because desulfation and/or further sulfation of the isolated macromolecules largely influenced their in vitro anti-HSV-1 activity.
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