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Preparation of a 3'-azido-3'-deoxythymidine (AZT) derivative, which is blood-brain barrier permeable
Jungkyun Im1, Wanil Kim, Kyong-Tai Kim
1Department of Chemistry, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
Abstract:
The anti-AIDS drug AZT was covalently attached to the recently reported sorbitol-G8 transporter, and the conjugate was found to target mitochondria in HeLa cells and readily cross the blood-brain barrier (BBB) to gain access into the mouse brain, suggesting the potential of these molecular transporters as practical central nervous system (CNS) delivery vectors.
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