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Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
Dimensions of Health and Illness01:21

Dimensions of Health and Illness

The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...

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Related Experiment Video

Updated: Jun 21, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

[On human ageing and longevity--2. Internal determinants].

R Brdicka1

  • 1Ustav hematologie a krevní transfuze, Praha. molgen@uhkt.cz

Casopis Lekaru Ceskych
|August 1, 2009
PubMed
Summary
This summary is machine-generated.

Genetic factors significantly impact longevity and aging. Studying progeria syndromes and using experimental animals helps identify genes that control lifespan and aging processes at cellular and organism levels.

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Last Updated: Jun 21, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
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Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

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Area of Science:

  • Genetics and Molecular Biology
  • Gerontology
  • Developmental Biology

Context:

  • Aging is a complex biological process influenced by numerous factors.
  • Understanding the genetic basis of aging is crucial for developing interventions.
  • Progeria syndromes offer insights into accelerated aging mechanisms.

Purpose:

  • To explore the genetic determinants of longevity and postponed aging.
  • To review the role of experimental animal models in aging research.
  • To identify genetic pathways involved in cellular and organismal aging.

Summary:

  • Genetic factors play a substantial role in determining longevity and the aging process.
  • Research on progeria syndromes and experimental animals has been effective in identifying lifespan-influencing genes.
  • Expression analysis reveals key genetic pathways involved in longevity at both cellular and organismal levels.

Impact:

  • Provides a foundation for understanding the genetic architecture of aging.
  • Highlights the utility of animal models in dissecting complex biological processes.
  • Contributes to the development of theories explaining the multifaceted nature of aging.