[Cooperativity between surface receptors and cytoskeleton]

Numerous physiological reactions of cells in dependence on ligand receptor interactions, e.g. variation of growth and division, locomotion and intracellular movement, cell shape and others, depend directly or indirectly on the functional state of the cytoskeleton. Relations between ligand-mediated receptor movements (preferentially for interferon) at the cell surface, the internalization and intracellular transport are discussed in the context of structural and functional properties of the cytoskeleton (especially of the microtubule system). As basic aspects of the cooperation between cytoskeleton and receptors are regarded both the unstable structural-temporal interactions between receptor/ligand complexes and the cytoskeleton, the generation of force and movement, and the activation of the cytoskeleton to transport competence for receptor/ligand complexes.