Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stereotactic hyperthermia for brain tumors.

H Yokote1, N Komai, E Nakai

  • 1Department of Neurological Surgery, Wakayama Medical College, Japan.

Stereotactic and Functional Neurosurgery
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum retinol levels are associated with brain volume loss in patients with multiple sclerosis.

Multiple sclerosis journal - experimental, translational and clinical·2017
Same author

Spinal cord ring enhancement in patients with neuromyelitis optica.

Acta neurologica Scandinavica·2015
Same author

Percutaneous transluminal angioplasty for intracranial arteriosclerotic lesions.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2010
Same author

Intra-arterial Thrombolytic Therapy for Acute Vertebrobasilar Artery Occlusion.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2010
Same author

Clinical results and complications of endovascular treatment for intracranial aneurysms.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2010
Same author

Percutaneous Transluminal Angioplasty for Bilateral ICA Occlusive Lesions.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2010

Localized hyperthermia using CT-stereotactic surgery effectively treated malignant brain tumors in cats and humans. Combining this therapy with chemotherapy showed significant efficacy for gliomas.

Area of Science:

  • Oncology
  • Neurosurgery
  • Medical Physics

Background:

  • Malignant brain tumors present significant therapeutic challenges.
  • Localized hyperthermia offers a targeted approach to cancer treatment.
  • Computed tomography (CT)-stereotactic surgery provides precise localization for interventions.

Observation:

  • Experimental studies demonstrated localized hyperthermia reaching over 43.7°C in feline brains near radiofrequency electrodes.
  • MCNU (Nimustine) drug concentration increased significantly in hyperthermia-treated brain regions.
  • Clinical application involved 7 malignant deep-seated gliomas and 21 metastatic brain tumors.

Findings:

  • Localized radiofrequency hyperthermia combined with stereotactic surgery was effective for treating malignant brain tumors.

Related Experiment Videos

  • This combination therapy demonstrated particular efficacy for gliomas located less than 30 mm deep.
  • Hyperthermia enhanced the delivery and concentration of chemotherapy agents within the targeted brain tissue.

    • Implications:

    • CT-stereotactic localized hyperthermia represents a promising therapeutic strategy for malignant brain tumors.
    • The enhanced drug delivery observed suggests improved chemotherapeutic outcomes.
    • This minimally invasive approach holds potential for improving patient survival and quality of life in neuro-oncology.