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Updated: Jun 21, 2026
09:14
An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay
Published on: January 26, 2019
[Practical pediatric aspects of palivizumab]
O Battisti1, K Vandenbosch, K Nyaamugabo
1Service de Pédiatrie et Néonatalogie, Faculté de Médecine, ULG, CHU de Liège, Belgique. oreste.battisti@chu.ulg.ac.be
Revue Medicale De Liege
|August 1, 2009
Summary
Palivizumab is a monoclonal antibody that reduces respiratory syncytial virus (RSV) complications in high-risk infants. This preventive measure is recommended after simpler strategies, considering its cost and RSV
Area of Science:
- Immunology
- Pediatrics
- Pharmacology
Context:
- Respiratory Syncytial Virus (RSV) bronchiolitis poses significant risks to vulnerable infants.
- Specific infant populations are identified as high-risk for severe cardio-respiratory impairment due to RSV.
Purpose:
- To outline the criteria for identifying infants at risk of severe RSV bronchiolitis.
- To describe the administration and efficacy of palivizumab (Synagis) as a preventive therapy.
Summary:
- Palivizumab, a monoclonal antibody, is indicated for infants with prematurity, chronic lung disease, congenital heart conditions, or severe immunodeficiency.
- Administered monthly via intramuscular injection, it targets RSV to reduce mortality and morbidity.
- Its use is recommended following simpler preventive measures due to cost considerations.
Impact:
- Demonstrates a reduction in mortality and morbidity among at-risk infants receiving palivizumab.
- Highlights the importance of targeted pharmacological intervention in pediatric respiratory infections.
- Emphasizes a comprehensive approach to bronchiolitis prevention, integrating both simple measures and advanced therapies.
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