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Updated: Jun 21, 2026
07:13
Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)
Published on: March 25, 2016
[Common variable immunodeficiency in pregnancy (set of case reports)]
B Kurecová1, P Janků, J Litzman
1Gynekologicko-porodnická klinika LF MU a FN, Brno. bkurecova@centrum.cz
Ceska Gynekologie
|August 1, 2009
Summary
Pregnant women with Common Variable Immunodeficiency (CVID) require specific immunoglobulin replacement therapy. This treatment ensures maternal health and adequate IgG transfer for healthy newborns.
Area of Science:
- Immunology
- Maternal-Fetal Medicine
Context:
- Common Variable Immunodeficiency (CVID) is a primary immunodeficiency affecting antibody production, leading to recurrent infections.
- Improved management of CVID allows affected women to achieve pregnancy.
- Pregnancy in CVID patients necessitates careful immunoglobulin management for both mother and fetus.
Purpose:
- To evaluate the safety and efficacy of immunoglobulin replacement therapy during pregnancy in women with CVID.
- To assess the impact of treatment regimens on IgG transfer to the fetus and newborn.
Summary:
- This study presents case reports of five pregnant women with CVID receiving intravenous immunoglobulins (IVIG).
- Treatment regimens were adjusted to ensure adequate maternal IgG levels and facilitate placental transfer.
- All pregnancies were carried to term, with labor induced after the final IVIG infusion, and resulted in healthy newborns.
Impact:
- Demonstrates that managed immunoglobulin therapy enables successful pregnancies in women with CVID.
- Highlights the importance of tailored IVIG protocols for protecting pregnant CVID patients and their infants.
- Supports the continuation of immunoglobulin replacement therapy throughout pregnancy for hypogammaglobulinemic women.
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