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Updated: Jun 21, 2026
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
[Diabetic nephropathy and primary glomarular diseases]
Kresimir Galesić1, Mirjana Sabljar-Matovinović, Ingrid Prkacin
1Odjel nefrologije, Interna klinika, KB Dubrava, Zagreb. kresog@kbd.hr
Lijecnicki Vjesnik
|August 1, 2009
Summary
Primary glomerular diseases are rare in diabetic patients but can occur alongside diabetic nephropathy. Identifying these conditions is crucial for effective treatment and improved kidney outcomes.
Area of Science:
- Nephrology
- Diabetology
- Pathology
Context:
- Diabetic nephropathy is a common complication of diabetes mellitus.
- Primary glomerular diseases are rarely diagnosed in diabetic patients.
- Nondiabetic glomerular diseases can be superimposed on diabetic nephropathy.
Purpose:
- To investigate the occurrence and impact of primary glomerular diseases in diabetic patients.
- To highlight the importance of recognizing nondiabetic renal diseases in the diabetic population.
- To analyze cases of diabetic patients with proteinuria and renal function decline without retinopathy.
Summary:
- This study reports on diabetic patients who underwent renal biopsy due to massive nephrotic proteinuria, non-nephrotic proteinuria, or deteriorating renal function, particularly when diabetic retinopathy was absent.
- Pathohistological examination revealed various types of primary glomerular diseases in these patients.
- The diagnosis and treatment of these superimposed glomerular diseases were found to improve renal prognosis in some individuals.
Impact:
- Early recognition and treatment of nondiabetic glomerular diseases can significantly alter the prognosis of renal disease in diabetic patients.
- This approach offers a potential for better management of kidney complications in diabetes.
- Highlights the need for thorough renal evaluation in diabetic patients presenting with atypical urinary abnormalities.
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