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Relation between red cell distribution width with echocardiographic parameters in patients with acute heart failure
Jaewon Oh1, Seok-Min Kang, Namki Hong
1Cardiology Division, Yonsei Cardiovascular Center and Cardiovascular Research Institute, Seoul, Korea.
Journal of Cardiac Failure
|August 1, 2009
Summary
Red cell distribution width (RDW) is linked to elevated left ventricular filling pressure in acute heart failure (AHF). Higher RDW levels correlate with increased E/E', a marker of diastolic dysfunction.
Area of Science:
- Cardiology
- Clinical Medicine
- Biomarker Research
Background:
- Red cell distribution width (RDW) is an emerging prognostic marker in heart failure.
- The relationship between RDW and echocardiographic findings in acute heart failure (AHF) remains understudied.
Purpose of the Study:
- To investigate the association between RDW and echocardiographic parameters in patients with AHF.
- To determine if RDW can serve as a predictor of elevated left ventricular filling pressure (LVFP) in AHF.
Main Methods:
- Analysis of laboratory and echocardiographic data from 100 AHF patients.
- Assessment of RDW, N-terminal pro-brain natriuretic peptide (NT-proBNP), and echocardiographic indices including E/E'.
- Statistical analysis including multiple linear regression and logistic regression.
Main Results:
- RDW was independently correlated with E/E", a measure of LVFP (P = .001).
- Higher RDW tertiles were associated with increased E/E", and NT-proBNP levels.
- An optimal RDW cutoff of 13.45% predicted E/E" > 15, indicating elevated LVFP (AUC 0.633, P < .05).
- RDW showed additive predictive value with NT-proBNP for elevated LVFP.
Conclusions:
- A novel association exists between elevated RDW and increased E/E" in AHF patients.
- RDW may represent a simple, accessible biomarker for assessing elevated LVFP in AHF.
- Further research is warranted to explore the clinical utility of RDW in AHF management.
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