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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

The prognostic value of the Tpeak-Tend interval in patients undergoing primary percutaneous coronary intervention for

Christian Haarmark1, Peter R Hansen, Esben Vedel-Larsen

  • 1Laboratory of Experimental Cardiology, University of Copenhagen, Copenhagen, Denmark.

Journal of Electrocardiology
|August 1, 2009
PubMed

Insights

Pre-procedure Tpeak-Tend interval (TpTe) in ST-segment elevation myocardial infarction (STEMI) patients predicts mortality. The QT interval increased post-primary percutaneous coronary intervention (pPCI).

Area of Science:

  • Cardiology
  • Electrophysiology
  • Clinical Research

Background:

  • The Tpeak-Tend interval (TpTe) is associated with increased risk of arrhythmias.
  • Investigating TpTe before and after primary percutaneous coronary intervention (pPCI) in ST-segment elevation myocardial infarction (STEMI) patients is crucial.

Purpose of the Study:

  • To evaluate the Tpeak-Tend interval (TpTe) in ST-segment elevation myocardial infarction (STEMI) patients before and after primary percutaneous coronary intervention (pPCI).
  • To determine if TpTe predicts all-cause mortality in STEMI patients undergoing pPCI.

Main Methods:

  • Included 101 first-time STEMI patients treated with pPCI.
  • Measured Tpeak-Tend interval (TpTe) on digital electrocardiograms pre- and post-pPCI.
  • Assessed all-cause mortality during a mean follow-up of 22 months.

Main Results:

  • No significant difference in TpTe was observed pre- and post-pPCI (104 ms vs 106 ms, P = .59).
  • A prolonged pre-pPCI TpTe (>100 ms) significantly predicted increased all-cause mortality (HR 10.5).
  • Both uncorrected QT and Fridericia-corrected QT intervals were significantly prolonged after pPCI.

Conclusions:

  • Pre-pPCI Tpeak-Tend interval (TpTe) is a significant predictor of long-term all-cause mortality in STEMI patients.
  • The QT interval increases following primary percutaneous coronary intervention (pPCI) in STEMI patients.
Abstract

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