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Longitudinal Follow-Up of Urinary Tract Infections and Their Treatment in Mice using Bioluminescence Imaging
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Diplopia and fluoroquinolones.

Frederick W Fraunfelder1, Frederick T Fraunfelder

  • 1Department of Ophthalmology (Casey Eye Institute), Oregon Health & Science University, 3375 SW Terwilliger Blvd., Portland, OR 97239, USA. eyedrug@ohsu.edu

Ophthalmology
|August 1, 2009
PubMed
Summary
This summary is machine-generated.

This study suggests a possible link between fluoroquinolone antibiotics and the development of diplopia (double vision). The findings are based on analyzing adverse drug reaction reports, with some cases showing improvement after stopping the medication.

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Area of Science:

  • Ophthalmology
  • Pharmacology
  • Clinical Toxicology

Background:

  • Fluoroquinolones are broad-spectrum antibiotics.
  • Diplopia is a visual disturbance characterized by double vision.

Purpose of the Study:

  • To investigate a potential association between fluoroquinolone use and the occurrence of diplopia.
  • To analyze case reports of diplopia in patients treated with fluoroquinolones.

Main Methods:

  • A retrospective database study analyzing spontaneous adverse drug reaction (ADR) reports.
  • Data collected from the National Registry of Drug-Induced Ocular Side Effects, WHO, and FDA.
  • Inclusion of 171 case reports detailing fluoroquinolone type, patient demographics, ADR onset, dosage, and dechallenge/rechallenge information.

Main Results:

  • 171 cases of diplopia linked to fluoroquinolones were reported, with a median age of 51.6 years.
  • Median time to ADR onset was 9.6 days; 53 reports showed positive dechallenge and 5 showed positive rechallenge.
  • Associated conditions included tendinitis in 17 subjects and use of anti-inflammatory steroids in 4 patients.

Conclusions:

  • The World Health Organization criteria classify the fluoroquinolone-diplopia association as 'possible'.
  • Causality is supported by temporal relationship, dechallenge/rechallenge data, and a plausible mechanism involving extraocular muscle tendinitis.