Related Experiment Video
Updated: Jun 21, 2026

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
Published on: October 29, 2014
[To study of etiopathogenetic peculiarities of meningitis in children]
Abstract:
The aim of the present study was to reveal some etio-pathogenetic aspects of bacterial meningitis in children. The complex clinical and microbiological investigation of 14 year old 66 children with meningeal and infectious syndromes was conducted. Bacterial meningitis was diagnosed in 90,9% patients. The meningococcal meningitis was diagnosed in 18 (30%) patients, H.influenzae meningitis--in 9 (15%), S.pneumoniae--in 8 (13,3%). Meningitis as a monoinfection was revealed in 85% cases; mixed infection--in 15%. In 28 patients the etiologic agents of disease were gram-negative bacteria, in 16 children--gram-positive.
Insights
This study investigated bacterial meningitis in children, finding it in 90.9% of cases. Common causes included meningococcal, H. influenzae, and S. pneumoniae, with most cases being monoinfections.
Area of Science:
- Pediatrics
- Infectious Diseases
- Microbiology
Background:
- Bacterial meningitis remains a significant cause of morbidity and mortality in children.
- Understanding the etio-pathogenesis is crucial for effective treatment and prevention.
Purpose of the Study:
- To investigate the etio-pathogenetic aspects of bacterial meningitis in pediatric patients.
- To identify the causative agents and patterns of infection.
Main Methods:
- A complex clinical and microbiological investigation was conducted.
- The study included 66 children presenting with meningeal and infectious syndromes.
Main Results:
- Bacterial meningitis was diagnosed in 90.9% of the investigated children.
- Key identified pathogens included Neisseria meningitidis (30%), Haemophilus influenzae (15%), and Streptococcus pneumoniae (13.3%).
- Meningitis occurred as a monoinfection in 85% of cases and a mixed infection in 15%.
Conclusions:
- Gram-negative bacteria were identified as etiologic agents in 28 patients, and gram-positive bacteria in 16.
- The findings highlight the diverse microbial landscape of pediatric bacterial meningitis.
Related Concept Videos
Bacterial Meningitis I: Introduction
Bacterial Meningitis II: Pathophysiology
Viral Meningitis
Bacterial Meningitis
Encephalitis l: Introduction
Encephalitis ll: Pathophysiology
