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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Tongue dysmorphology in craniofacial microsomia
Elliott H Chen1, Russell R Reid, Chuma Chike-Obi
1Philadelphia, Pa.; Chicago, Ill., and Krakow, Poland From the Division of Plastic Surgery, The Children's Hospital of Philadelphia, University of Pennsylvania; the Section of Plastic and Reconstructive Surgery, Comer Children's Hospital at the University of Chicago Medical Center; and the University Children's Hospital of the Jagiellonian University.
Tongue dysmorphology is common in craniofacial microsomia, often overlooked but linked to facial deformities. Early detection and intervention improve speech outcomes in affected individuals.
Area of Science:
- Medical Science
- Genetics
- Developmental Biology
Background:
- Craniofacial microsomia is a common craniofacial anomaly.
- Tongue dysmorphism is underreported in craniofacial microsomia.
- This review investigates tongue dysmorphology prevalence and its relation to craniofacial microsomia.
Purpose of the Study:
- To determine the prevalence of tongue dysmorphology in patients with craniofacial microsomia.
- To explore the relationship between tongue anomalies and speech development.
- To correlate tongue dysmorphology with other craniofacial deformities.
Main Methods:
- A 20-year retrospective study analyzed documented tongue anomalies and speech development.
- A 1-year prospective study assessed the true prevalence of tongue dysmorphology.
- Correlation analysis was performed between tongue anomalies and hard/soft tissue deformities.
Main Results:
- Retrospective: 4.8% prevalence of tongue dysmorphology.
- Prospective: 43.6% prevalence of tongue dysmorphology.
- Tongue dysmorphology positively correlated with craniofacial deformity severity; most cases were mild and treatable with speech therapy/surgery.
Conclusions:
- Tongue dysmorphologies in craniofacial microsomia are frequent but often missed.
- The association suggests a potential common developmental error or interdependence of growth centers.
- Addressing tongue anomalies is crucial for managing craniofacial microsomia and improving speech outcomes.
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