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Deconvoluting the 'omics' for organ transplantation
1Department of Pediatrics, Stanford University, Stanford, California, USA. msarwal@stanford.edu
Current Opinion in Organ Transplantation
|August 1, 2009
Summary
Advancements in omic technologies are enabling the discovery of novel biomarkers for organ transplant rejection and tolerance. Translating these biomarkers requires interdisciplinary collaboration and rigorous validation for clinical application.
Area of Science:
- Biomarker discovery in organ transplantation
- Application of omic technologies in transplantation research
Background:
- Increasing need for diagnostic and prognostic biomarkers in diseases.
- Growing availability of genomic and proteomic data facilitates biomarker discovery.
Purpose of the Study:
- Review recent applications of omic technologies in organ transplantation.
- Highlight the potential of omics for understanding graft injuries and developing biomarkers.
Main Methods:
- Utilizing high-throughput omic techniques including genomics, metabolomics, antibiomics, peptidomics, and proteomics.
- Analyzing data to understand mechanisms of graft injury and identify biomarkers.
Main Results:
- Omic technologies aid in understanding specific graft injuries.
- Development of novel biomarkers for acute rejection, chronic rejection, and operational tolerance is underway.
- Potential biomarkers identified for various aspects of transplant monitoring.
Conclusions:
- Translating biomarkers from research to clinical practice is challenging.
- Requires collaboration between immunologists, molecular biologists, transplantation specialists, geneticists, and bioinformaticians.
- Prospective validation studies with large patient cohorts are essential for clinical implementation.
