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Nephrotic-range proteinuria with small glomerular fibrillary deposits in a patient on diphenylhydantoin treatment
Ahmet Alper Kiykim1, Gultekin Genctoy, Mehmet Horoz
1Department of Internal Medicine, Division of Nephrology, Faculty of Medicine, University of Mersin, Mersin, Turkey.
Background:
Although the exact role of the diphenylhydantoin treatment on the immune system is still unclear, prolonged administration of diphenylhydantoin has been suggested to be associated with immune-based disorders and syndromes.
Case Report:
A case of fibrillary glomerulonephritis associated with DPH treatment is reported. This is the first reported case of fibrillary glomerulonephritis associated with this commonly used common anticonvulsive drug.
Conclusions:
A more routine surveillance for proteinuria in patients receiving DPH is recommended.
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