Related Experiment Video
Updated: Jun 21, 2026

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
Published on: May 28, 2021
[Skin protection. From TRGS 401 to guidelines on "occupational skin protection products"]
1Abt. für klinische & experimentelle Berufsdermatologie, BGFA-Forschungsinstitut für Arbeitsmedizin der DGUV, Ruhr-Universität Bochum, Bürkle-de-la Camp- Platz 1, 44789, Bochum. fartasch@bgfa.de
Abstract:
The technical standards for hazardous substances (TRGS) reflect the currently achievable technical safety, occupational-medical, hygienic and scientific standards for production, distribution and handling of hazardous substances. The TRGS 401 "Risks resulting from skin contact--determination, evaluation, measures" gives important information regarding occupational hazardous exposure of the skin and the measures for prevention. A definition for wet work is given under which occlusion by moisture impermeable protective gloves and contacts to wet environments are included. Both the TRGS 401 and the AWMF S1 guidelines on "Occupational protection products" place emphasis on the fact that the protective effectiveness of topical skin products for protection, care and cleansing should be proven by in vivo methods.
Related Concept Videos
Personal Protective Equipment
PPE Use in Healthcare Settings I: Donning
PPE Use in Healthcare Settings II: Doffing
Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Standard Precaution
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...

