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Updated: Jun 21, 2026
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
[Renal dysfunction as a marker of cardiovascular risk]
M Cirillo1, L Del Giudice, G Bilancio
1Nefrologia, Seconda Universita' degli Studi, Napoli, Italy. massimo.cirillo@unina2.it
Summary
Assessing both urinary albumin excretion (UAE) and estimated glomerular filtration rate (eGFR) together offers a more comprehensive evaluation of kidney dysfunction and cardiovascular risk than either marker alone.
Area of Science:
- Nephrology
- Cardiology
- Epidemiology
Context:
- Cardiovascular risk assessment often involves evaluating urinary albumin excretion (UAE) and estimated glomerular filtration rate (eGFR).
- The complementary information provided by UAE and eGFR for cardiovascular risk stratification remains unclear.
- The Gubbio study analyzed UAE, eGFR, cardiovascular risk factors, and cardiovascular disease incidence in individuals aged 45-64.
Purpose:
- To determine if UAE and eGFR provide complementary information for assessing cardiovascular risk.
- To investigate the combined utility of UAE and eGFR in identifying kidney dysfunction and predicting cardiovascular disease incidence.
Summary:
- High UAE and low eGFR were defined based on deciles in the study population.
- Kidney dysfunction was more prevalent when identified by both UAE and eGFR, as these markers often identified different individuals.
- Individuals with both high UAE and low eGFR exhibited a significantly higher hazard ratio for incident cardiovascular disease (HR=5.93) compared to those with only one abnormal marker.
Impact:
- Concomitant evaluation of UAE and eGFR is recommended for a more adequate assessment of kidney dysfunction.
- Combined UAE and eGFR assessment can improve cardiovascular risk stratification.
- This approach aids in identifying individuals at higher risk for cardiovascular events.
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