Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nitric oxide is involved in the expression of neocortical spike-and-wave spindling episodes in DBA/2J mice.

The Journal of pharmacy and pharmacology·2003
Same author

Delayed presentation of congenital diaphragmatic Bochdalek hernia. Case report.

Minerva pediatrica·2003
Same author

Spectrum of SCN1A mutations in severe myoclonic epilepsy of infancy.

Neurology·2003
Same author

Family study of epilepsy in first degree relatives: data from the Italian Episcreen Study.

Seizure·2003
Same author

Alterations in smooth muscle contractile and cytoskeleton proteins and interstitial cells of Cajal in megacystis microcolon intestinal hypoperistalsis syndrome.

Journal of pediatric surgery·2003
Same author

Evidence for the presence of both peroxisome proliferator-activated receptors alpha and beta in the rat spinal cord.

Journal of chemical neuroanatomy·2003

Related Experiment Video

Updated: Jun 21, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

[Living donor kidney transplant: the crossover modality].

M Barsotti1, U Boggi, C Tregnaghi

  • 1U.O. Nefrologia dei Trapianti e Dialisi 1, A.O.U. Pisana, Pisa.

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
|August 1, 2009
PubMed
Summary

Living donor kidney transplantation (LKD) offers superior outcomes for ESRD patients. Paired exchange LKD overcomes ABO incompatibility and cross-match issues, making transplants possible for more recipients.

More Related Videos

Murine Kidney Transplant Technique
08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

Related Experiment Videos

Last Updated: Jun 21, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Murine Kidney Transplant Technique
08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Surgical Innovation

Context:

  • Living donor kidney transplantation (LKD) is the optimal choice for end-stage renal disease (ESRD) patients due to superior organ quality and survival rates.
  • ABO incompatibility and positive cross-matches are significant barriers to LKD, limiting options for many patients.
  • Advancements in immunosuppression, apheresis, and immunoglobulin therapy aim to overcome these biological hurdles.

Purpose:

  • To evaluate the efficacy and clinical outcomes of paired exchange living donor kidney transplantation (PE-LKD) as a strategy to overcome immunological barriers.
  • To highlight the role of international and national paired exchange programs in facilitating LKD.
  • To present the Italian experience with PE-LKD, including early national and center-specific initiatives.

Summary:

  • Paired exchange LKD involves exchanging incompatible donor-recipient pairs to enable transplantation.
  • International guidelines recommend paired exchange to circumvent blood type and cross-match incompatibilities.
  • The first Italian PE-LKD occurred in 2005, followed by a national program in 2006, demonstrating successful implementation.

Impact:

  • PE-LKD provides a viable solution for ESRD patients facing immunological incompatibility, expanding access to LKD.
  • Clinical results from paired exchange programs are comparable to direct LKD, offering comparable survival benefits.
  • This approach enhances the quality of life for uremic patients by enabling otherwise impracticable kidney transplants.