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C-reactive protein and atrial fibrillation in idiopathic dilated cardiomyopathy

Shimo Dai1, Shu Zhang, Ying hua Guo

  • 1Center for Arrhythmia Diagnosis and Treatment, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Street 167, Xicheng District, Beijing 100037, P.R. China.

Clinical Cardiology
|August 1, 2009
PubMed

Insights

Plasma C-reactive protein (CRP) is elevated in patients with idiopathic dilated cardiomyopathy and atrial fibrillation (AF). Higher CRP levels correlate with increased AF prevalence in these patients, suggesting inflammation.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation

Background:

  • Elevated C-reactive protein (CRP) is noted in atrial fibrillation (AF) patients.
  • Limited research exists on CRP in idiopathic dilated cardiomyopathy (IDCM) with AF.

Purpose of the Study:

  • To investigate CRP levels in IDCM patients with AF.
  • To determine the association between CRP and AF prevalence in IDCM.

Main Methods:

  • Compared CRP levels in 242 IDCM patients with AF to 280 control IDCM patients.
  • Utilized multivariate logistic regression to identify correlating factors.

Main Results:

  • CRP levels were significantly higher in IDCM patients with AF (4.59 mg/L) versus controls (2.81 mg/L).
  • AF prevalence increased with higher plasma CRP levels in IDCM.
  • Body mass index, AF, and white blood cell count correlated with CRP levels.

Conclusions:

  • IDCM patients with AF exhibit higher plasma CRP levels.
  • Increased CRP is associated with a higher prevalence of AF in IDCM.
  • Findings suggest inflammation in IDCM patients with AF.
Abstract

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