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Updated: Jun 21, 2026
Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
[Preparation and characterization of hydroxycamptothecin nanoparticles of amphiphilic block copolymer]
1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. xfiona224@yahoo.com.cn
Objective:
To prepare hydroxycamptothecin nanoparticles of amphiphilic block copolymer and study its characterization initially.
Methods:
Polyethyleneglycol-polycaprolactone (PEG-PCL) was synthesized and its structure was characterized by 1H-NMR. The HCPT-PEG-PCL-NPs were prepared by solvent-diffusion method using PEG-PCL block copolymer as a matrix and HCPT as an antitumor agent. Then the obtained NPs were evaluated and the physical stabilities of both suspl and freeze drying powder were investigated.
Results:
The mean particle size of the prepared NPs was 164.5 nm, polydispersity index (PI) was 0.14, drug loading (DL) was 5.49%, entrapment efficiency (EE) was 83.2%, zeta potential was -26.1 mV. The physical stability of freeze drying powder was better and hot environment seemed to be bad for the stability.
Conclusion:
The HCPT-PEG-PCL-NPs increase the solubility of HCPT in water and are valuable for the development of the novel dosage form of HCPT.
