An asymmetric hetero-claisen approach to 3-alkyl-3-aryloxindoles
Nicolas Duguet1, Alexandra M Z Slawin, Andrew D Smith
1EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK.
Organic Letters
|August 4, 2009
Abstract:
The reaction of a chiral N-phenylnitrone derived from Garner's aldehyde with alkylarylketenes generates 3-alkyl-3-aryloxindoles directly in excellent yields and with good to excellent levels of enantioselectivity (up to 90% ee).
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