Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 21, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

Changes in calcium-binding protein expression in human cortical contusion tissue.

Efraín Buriticá1, Liliana Villamil, Francisco Guzmán

  • 1Centro de Estudios Cerebrales, Facultad de Salud, Universidad del Valle , Cali, Valle, Colombia.

Journal of Neurotrauma
|August 4, 2009
PubMed
Summary

Traumatic brain injury (TBI) alters cortical interneurons and astrocytes, potentially leading to epilepsy. Researchers observed significant changes in calcium-binding proteins and glial fibrillary acidic protein expression in human TBI samples.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New directions for complex systems in contemporary neuroscience: a morphodynamic and emergent function approach.

Frontiers in computational neuroscience·2026
Same author

Molecular and Functional Alterations of P-Glycoprotein in a Genetic Model of Epilepsy: Insights from the Wistar Audiogenic Rat.

International journal of molecular sciences·2026
Same author

Consistent changes in global gene expression patterns despite strong variation in individual gene expression in the male mouse hippocampus following early life stress.

Neurobiology of stress·2026
Same author

From comorbidity to continuum: Alzheimer's disease and epilepsy are connected-now what?

Neuroscience and biobehavioral reviews·2026
Same author

Editorial: Challenging our understanding of neurological and neuropsychiatric disorders by means of hybrid biological and technological tools: novel approaches in computational neuroscience, neuroengineering, and artificial intelligence.

Brain research·2026
Same author

Dysregulated Plasticity in Serotonin, Galanin, and Opioid Systems Contributes to Limbic Seizure Recruitment in Wistar Audiogenic Rat.

Journal of neurochemistry·2026

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Pathology

Background:

  • Traumatic brain injury (TBI) can lead to cellular changes like gliosis and cell death, initiating epileptogenesis.
  • Dysfunction of inhibitory cortical components post-TBI may cause status epilepticus.
  • Understanding TBI's impact on human cortical interneurons and astrocytes is crucial for epilepsy research.

Purpose of the Study:

  • To analyze the response of cortical interneurons and astrocytes following TBI in human samples.
  • To investigate the expression of glial fibrillary acidic protein (GFAP) and calcium-binding proteins (CaBPs) in TBI-affected brain tissue.

Main Methods:

  • Evaluation of twelve human contusion samples from TBI patients.
  • Assessment of GFAP and CaBP immunoreactivity (IR).

More Related Videos

Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury
09:29

Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury

Published on: September 11, 2017

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

Related Experiment Videos

Last Updated: Jun 21, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury
09:29

Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury

Published on: September 11, 2017

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

  • Analysis of brain sectors with and without preserved cytoarchitecture using NeuN IR.

    • Main Results:

    • Significant loss of CaBP-IR in neuropil and somata in areas with complete NeuN-IR loss.
    • Less drastic CaBP-IR changes in areas with preserved cytoarchitecture.
    • Observed alterations in parvalbumin (PV), calbindin (CB), and calretinin (CR) expressing neurons, alongside increased GFAP-IR in specific regions.

    Conclusions:

    • TBI induces dynamic cellular changes in cortical interneurons and astrocytes.
    • These alterations, including changes in CaBP and GFAP expression, may contribute to epileptogenesis post-TBI.
    • The observed cellular changes could be linked to altered excitatory circuits and neuronal hyperexcitability, potentially underlying post-traumatic epilepsy.