Related Experiment Video

Updated: Jun 21, 2026

Using a Bipolar Electrode to Create a Temporal Lobe Epilepsy Mouse Model by Electrical Kindling of the Amygdala
09:49

Using a Bipolar Electrode to Create a Temporal Lobe Epilepsy Mouse Model by Electrical Kindling of the Amygdala

Published on: June 29, 2022

Tumor-associated epilepsy

Kiran F Rajneesh1, Devin K Binder

  • 1Department of Neurological Surgery, University of California, Irvine, California, USA.

Neurosurgical Focus
|August 4, 2009
PubMed

Insights

Tumor-associated epilepsy, a common complication of brain tumors, arises from changes in the tissue surrounding the tumor. Understanding these alterations may lead to novel treatments for drug-resistant seizures.

Area of Science:

  • Neuro-oncology
  • Epileptology
  • Pathophysiology

Background:

  • Tumor-associated epilepsy significantly contributes to patient morbidity.
  • Mechanisms include neuronal/glial dysfunction, vascular changes, and altered ionic/pH balance.
  • Perilesional tissue alterations are critical in seizure generation.

Purpose of the Study:

  • To explore the pathophysiological mechanisms of tumor-associated epilepsy.
  • To highlight the role of perilesional tissue in seizure generation.
  • To identify factors influencing seizure burden.

Main Methods:

  • Review of proposed pathophysiological mechanisms.
  • Analysis of clinical studies on tumor-associated seizures.
  • Examination of histopathological and location factors.

Main Results:

  • Tumor-associated seizures are typically focal with secondary generalization.
  • Seizures are often resistant to standard antiepileptic drugs.
  • Tumor characteristics and location independently affect seizure frequency.

Conclusions:

  • Perilesional tissue alterations are key to understanding tumor-associated epilepsy.
  • Further research into these mechanisms could yield new therapeutic strategies.
  • Targeting perilesional alterations may offer novel treatment avenues for resistant seizures.

More Related Videos

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury07:07

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Published on: February 10, 2020

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
Seizures ll: Types01:19

Seizures ll: Types

Seizures are sudden bursts of abnormal electrical discharge in the brain that interfere with normal function. They are commonly divided into three groups: focal seizures, generalized seizures, and other types that do not fit neatly into either category.Focal SeizuresFocal seizures begin in a single brain region. When awareness is preserved, they are called focal aware seizures and may cause sensations such as tingling, unusual smells, or flashing lights. When awareness is impaired, they are...
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...