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In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase
Published on: November 5, 2021
Chagas disease in Spain, the United States and other non-endemic countries
Joaquim Gascon1, Caryn Bern, María-Jesús Pinazo
1Centre de Salut Internacional, CRESIB, Hospital Clínic, IDIBAPS, c/Villarroel, 170, 08036, Barcelona, Spain. jgascon@clinic.ub.es
Abstract:
Due to recent trends in migration, there are millions of people from Chagas disease-endemic countries now living in North America, Europe, Australia and Japan, including thousands of people with Trypanosoma cruzi infection. Most infected individuals are not aware of their status. Congenital, transfusion- and/or transplant-associated transmission has been documented in the United States, Spain, Canada and Switzerland; most instances likely go undetected. High priorities include the implementation of appropriate screening, evaluation and clinical management, and better assessment of the true burden associated with this disease.
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