Related Experiment Video
Updated: Jun 21, 2026

08:30
Operant Procedures for Assessing Behavioral Flexibility in Rats
Published on: February 15, 2015
Neonatal ventral hippocampal lesions disrupt set-shifting ability in adult rats
1Department of Psychology, St. Mary's College of Maryland, 18952 E. Fisher Road, St. Mary's City, MD 20686, United States. ambrady@smcm.edu
Behavioural Brain Research
|August 4, 2009
Abstract:
Set-shifting in a T-maze task was assessed in rats with a neonatal ventral hippocampal lesion (NVHL), a proposed animal model of schizophrenia. NVHL animals tested as adults were impaired in shifting to a new rule; an increase in perseverative errors suggested that this impairment stemmed from an inability to suppress the previously learned strategy. The NVHL animals' performance is reminiscent of humans with prefrontal damage and patients with schizophrenia.

