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Published on: December 23, 2016
Dendrimers: emerging polymers for drug-delivery systems
Basavaraj K Nanjwade1, Hiren M Bechra, Ganesh K Derkar
1Department of Pharmaceutics, JN Medical College, KLE University, Belgaum-590010, India. bknanjwade@yahoo.co.in
Dendrimers are highly branched polymeric macromolecules with unique properties like uniform size and multivalency. These versatile materials are increasingly attractive for biological and drug-delivery applications, with commercialization on the horizon.
Area of Science:
- Polymer Chemistry
- Materials Science
- Nanotechnology
Background:
- Dendrimers represent a novel class of polymeric materials.
- Characterized by a highly branched 3D architecture, they offer extensive surface functionality and versatility.
Purpose of the Study:
- To provide a concise overview of dendrimer synthesis strategies.
- To discuss various types of dendrimers and their functionalities.
- To highlight key properties and potential applications of dendrimers.
Main Methods:
- Review of existing literature on dendrimer synthesis.
- Analysis of structure-property relationships in dendrimers.
- Exploration of current and emerging applications.
Main Results:
- Dendrimers exhibit unique properties including uniform size, high branching, water solubility, multivalency, defined molecular weight, and internal cavities.
- These properties make them highly suitable for biological and drug-delivery systems.
Conclusions:
- Dendrimers possess significant potential for advanced applications, particularly in medicine and drug delivery.
- Ongoing research and development are paving the way for the commercialization of dendrimer-based technologies.
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