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Updated: Jun 21, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

HPV induced triple neoplasms: a case report.

Valeria Visconti¹, Morena Antonilli, Filippo Bellati

¹Institute of Gynecology and Obstetrics, Sapienza University, viale del Policlinico, 155-00161 Rome, Italy. valeria.visconti@uniroma1.it

American Journal of Obstetrics and Gynecology

|August 4, 2009

Summary

The incidence of multiple primary cancers is rising. This report details the first documented case of a woman developing three distinct human papillomavirus (HPV)-induced cancers: cervical, vulvar, and head and neck.

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Area of Science:

Oncology
Virology
Gynecologic Oncology

Background:

Increasing incidence of multiple primary cancers observed over the past decade.
Human Papillomavirus (HPV) is a known oncogenic virus implicated in various malignancies.
Understanding the interplay of HPV in multifocal carcinogenesis is crucial for patient management.

Observation:

A unique case of a single patient presenting with three distinct primary neoplasms.
All three neoplasms were confirmed to be HPV-induced, highlighting a potential viral etiology.
The affected sites included the cervix, vulva, and head and neck region.

Findings:

This represents the first reported instance of a woman with three separate HPV-driven cancers.
The simultaneous or sequential development of these distinct carcinomas in one individual is highly unusual.

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Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

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Last Updated: Jun 21, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

Diagnostic confirmation involved histopathology and HPV DNA testing for all neoplasms.

Implications:

Suggests a potential for broader HPV-related oncogenesis than previously understood.
Highlights the importance of considering HPV in patients with multiple, seemingly unrelated, cancers.
May necessitate revised screening protocols and surveillance strategies for high-risk individuals.