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Cytomegalovirus infection presenting as hepatitis
T Laskus1, E Lupa, J Cianciara
1Department of Hepatology, Institute of Infectious and Parasitic Diseases, Warsaw, Poland.
Digestion
|January 1, 1990
Summary
Cytomegalovirus infection can cause acute hepatitis in adults, presenting with jaundice and mild symptoms. Recovery was observed within 3-5 weeks, similar to other hepatitis types.
Area of Science:
- Hepatology
- Virology
- Infectious Diseases
Background:
- Acute hepatitis is a significant cause of hospitalization.
- Cytomegalovirus (CMV) is a common viral infection with varied clinical manifestations.
Purpose of the Study:
- To investigate the incidence and clinical characteristics of cytomegalovirus infection presenting as acute hepatitis.
- To compare CMV hepatitis with other common forms of viral hepatitis.
Main Methods:
- Retrospective analysis of 530 patients hospitalized for acute hepatitis between 1986-1988.
- Diagnosis of cytomegalovirus infection in symptomatic patients.
Main Results:
- Cytomegalovirus infection was diagnosed in 5 (0.9%) of the patients.
- All CMV-infected patients presented with symptomatic hepatitis and jaundice; 3 also experienced pruritus.
- Hematological changes were mild, and liver function tests were comparable to hepatitis A, B, and non-A, non-B.
- Biochemical abnormalities resolved within 3-5 weeks for all patients.
Conclusions:
- Cytomegalovirus is an uncommon but identifiable cause of acute hepatitis in hospitalized adults.
- CMV hepatitis exhibits clinical and biochemical features similar to other viral hepatitis types.
- The prognosis for CMV hepatitis is generally favorable, with complete biochemical recovery within weeks.