Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Low molecular weight heparins: an introduction.

S Coccheri1

  • 1Chair of Clinical Pathophysiology, University Hospital S. Orsola, Bologna, Italy.

Haemostasis
|January 1, 1990
PubMed
Summary

Low molecular weight heparins (LMWHs) are effective and safe for deep-vein thrombosis prophylaxis. Their administration is more convenient than unfractionated heparin, despite initial oversimplifications in understanding their antithrombotic mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biological and clinical effects of sulodexide in arterial disorders and diseases.

International angiology : a journal of the International Union of Angiology·2014
Same author

Antiplatelet therapy: criteria of choice in reversible and irreversible cerebral ischaemia.

Platelets·2010
Same author

Thromboxane Antagonism with terutroban in Peripheral Arterial Disease: the TAIPAD study.

Journal of thrombosis and haemostasis : JTH·2010
Same author

Has time come for a re-assessment of spa therapy? The NAIADE survey in Italy.

International journal of biometeorology·2007
Same author

Thrombophilia and venous thromboembolism. International consensus statement. Guidelines according to scientific evidence.

International angiology : a journal of the International Union of Angiology·2005
Same author

Effects of defibrotide in patients with chronic deep insufficiency. The PROVEDIS study.

International angiology : a journal of the International Union of Angiology·2004

Area of Science:

  • Pharmacology
  • Biochemistry
  • Thrombosis Research

Background:

  • Heparin fractions and fragments aid in understanding heparin's mechanism.
  • Fractionation identified key structural components like the pentasaccharide for anti-factor Xa activity.

Purpose of the Study:

  • To evaluate the efficacy and safety of low molecular weight heparins (LMWHs).
  • To assess the relationship between LMWH structure, activity, and antithrombotic effects.

Main Methods:

  • Heparin fractionation and fragmentation procedures.
  • Development and characterization of low molecular weight heparins (around 5,000 molecular weight).
  • Assessment of anti-factor Xa and anti-factor IIa activities and experimental antithrombotic effects.

Main Results:

  • Initial hypotheses regarding anti-factor Xa/anti-factor IIa ratios predicting antithrombotic activity and reduced hemorrhage were oversimplified.
  • Neither anti-factor Xa nor anti-factor IIa activity alone reliably predicts antithrombotic efficacy or hemorrhagic risk.

Conclusions:

  • Low molecular weight heparins (LMWHs) are as effective and safe as unfractionated heparin for deep-vein thrombosis prophylaxis.
  • LMWHs offer more convenient and practical administration compared to unfractionated heparin.

Related Experiment Videos