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Thyroid function and plasma cyclic AMP response to intravenous glucagon.

S N Madsen

    Acta Endocrinologica
    |August 1, 1977
    PubMed
    Summary
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    Thyroid status affects cyclic AMP response to glucagon. While treatment can normalize this response, some patients exhibit persistent changes, suggesting hormonal inertia.

    Area of Science:

    • Endocrinology
    • Molecular Biology
    • Metabolism

    Background:

    • Thyroid hormones significantly influence cellular metabolism and signaling pathways.
    • Cyclic adenosine monophosphate (cAMP) is a crucial second messenger involved in various cellular responses, including those stimulated by glucagon.

    Purpose of the Study:

    • To investigate the impact of hyperthyroidism and hypothyroidism on the glucagon-stimulated increase in plasma cyclic AMP.
    • To assess the diagnostic utility of the plasma cyclic AMP response to glucagon for evaluating thyroid states.
    • To examine the reversibility of altered cyclic AMP responses following treatment for thyroid dysfunction.

    Main Methods:

    • Studied plasma cyclic AMP levels in response to intravenous glucagon administration in healthy subjects, hyperthyroid patients, and hypothyroid patients.

    Related Experiment Videos

  • Re-evaluated a subset of treated hyperthyroid and hypothyroid patients after a minimum of 15 months of treatment.

    • Main Results:

    • Hyperthyroid patients exhibited an increased cyclic AMP response to glucagon, while hypothyroid patients showed a reduced response.
    • A significant number of hyperthyroid and hypothyroid patients displayed normal responses, indicating the test's limited sensitivity for peripheral thyroid states.
    • Treatment normalized cyclic AMP responses in most patients, but a persistent hyper-response to glucagon was observed in some treated hyperthyroid patients, suggesting hormonal inertia.

    Conclusions:

    • The glucagon-stimulated cyclic AMP response is altered in thyroid dysfunction but is not a consistently sensitive indicator of peripheral thyroid states.
    • Thyroid hormone effects on liver cAMP may not directly correlate with effects on other tissues.
    • Hormonal inertia may explain persistent alterations in glucagon sensitivity after normalization of thyroid hormone levels.