Related Experiment Video
Updated: Jun 21, 2026

Accessing Early Differentiation of Virus-Specific Follicular Helper CD4+ T Cell in Acute LCMV-Infected Mice
Published on: April 26, 2024
Fine-tuning of T cell responses during infection
Anca Dorhoi1, Stefan H E Kaufmann
1Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany. dorhoi@mpiib-berlin.mpg.de
Abstract:
Adequate control of infection relies on development of a tailored immune response according to the requirements of a given infection. This is achieved by the continuous crosstalk between innate and adaptive immunity. Pathogen diversity is deciphered via a plethora of receptors converging signals to adaptor molecules; tissue sites and environment generate additional signals that further influence T cell lineage decisions. Within this continuum of interactions, fine-tuning of the ensuing T cell responses together with plasticity of the committed T cells ensure development of balanced immune responses maintaining homeostasis. This review focuses on the multiple mechanisms that govern T cell differentiation during infection.
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