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Related Concept Videos

Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
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Maxam-Gilbert Sequencing01:05

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Related Experiment Video

Updated: Jun 21, 2026

Novel Sequence Discovery by Subtractive Genomics
09:40

Novel Sequence Discovery by Subtractive Genomics

Published on: January 25, 2019

Ancient repeat sequence derived from U6 snRNA in primate genomes.

Manel Hasnaoui1, Aurélien J Doucet, Oussama Meziane

  • 1Institut de Génétique Humaine, Centre National de la Recherche Scientifique, 141 Rue de la Cardonille, 34396 Montpellier Cedex 5, France.

Gene
|August 4, 2009
PubMed
Summary
This summary is machine-generated.

LINE-1 (L1) retrotransposons mobilized ancient U6 small nuclear RNA (snRNA) sequences. This ancient U6-derived repeat is present across primate genomes and likely originated during Euarchonta divergence.

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Published on: September 3, 2009

Area of Science:

  • Genomics
  • Molecular Biology
  • Evolutionary Biology

Background:

  • LINE-1 (L1) elements constitute a significant portion of the human genome, approximately 17%.
  • L1 elements are known to mobilize various genomic sequences, including pseudogenes, small non-coding RNAs (like tRNAs and snRNAs), and SINEs.
  • These mobilized elements contribute substantially to genome evolution, with L1 estimated to be responsible for at least 30% of the genome.

Purpose of the Study:

  • To investigate the mobilization of non-L1 RNAs by LINE-1 elements.
  • To identify and characterize ancient repeat sequences derived from U6 small nuclear RNA (snRNA) mobilized by L1.
  • To trace the evolutionary origin of these mobilized U6 snRNA sequences within primate and related genomes.

Main Methods:

  • Comparative genomic analysis of primate and Euarchonta genomes.
  • Bioinformatic identification of U6 snRNA-derived repeat sequences.
  • Phylogenetic analysis to determine the evolutionary history and origin of the identified repeats.

Main Results:

  • An ancient repeat sequence, derived from U6 snRNA and mobilized by L1, was identified.
  • This U6-derived repeat is conserved across all primate genomes analyzed.
  • The origin of this repeat was traced to the divergence of Euarchonta orders, including Scandentia, Dermoptera, Plesiadapiform (extinct), and Primates.

Conclusions:

  • LINE-1 retrotransposons played a role in the mobilization and propagation of ancient U6 snRNA sequences.
  • The identified U6-derived repeat represents a significant genomic feature with a deep evolutionary history within Euarchonta.
  • This finding sheds light on the mechanisms of non-coding RNA mobilization and its contribution to genome evolution.