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Updated: Jun 21, 2026

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies
Published on: December 29, 2021
Changes in the endocannabinoid system may give insight into new and effective treatments for cancer
Gianfranco Alpini1, Sharon Demorrow
1Department of Medicine, Texas A&M Health Science Center, College of Medicine, Temple, Texas, USA.
Abstract:
The endocannabinoid system comprises specific cannabinoid receptors such as Cb1 and Cb2, the endogenous ligands (anandamide and 2-arachidonyl glycerol among others) and the proteins responsible for their synthesis and degradation. This system has become the focus of research in recent years because of its potential therapeutic value several disease states. The following review describes our current knowledge of the changes that occur in the endocannabinoid system during carcinogenesis and then focuses on the effects of anandamide on various aspects of the carcinogenic process such as growth, migration, and angiogenesis in tumors from various origins.
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