Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential effects of cognitive task demands on gait performance and cognitive-motor interference in chronic stroke.

European journal of physical and rehabilitation medicine·2026
Same author

Transcranial direct current stimulation of the dorsolateral prefrontal cortex improves dual-task performance in people with stroke.

Journal of neuroengineering and rehabilitation·2026
Same author

Reactive lithium fluoride revitalizes bulk-interface Na-ion transport in all-solid-state PEO-based sodium batteries.

Chemical science·2026
Same author

Psychometric properties of the Community Balance and Mobility Scale for people with stroke.

European journal of physical and rehabilitation medicine·2026
Same author

Polyamine-Mediated Proton/TFSI<sup>-</sup> Dual Capture Enables High-Voltage PEO-Based All-Solid-State Li Batteries.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Psychometric Properties of the Balance Self-Efficacy Scale in People With Stroke.

Annals of rehabilitation medicine·2026
Same journal

Corrigendum to "Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide" [Biomaterials 42 (2015) 16442].

Biomaterials·2026
Same journal

An injectable Ce-MnCo LDH nanozyme gel with cascade catalytic activity for acute radiation proctitis in rats.

Biomaterials·2026
Same journal

Peptide coacervate-mediated siRNA delivery for dual PD-1/PD-L1 blockade to enhance colorectal cancer immunotherapy.

Biomaterials·2026
Same journal

A sonosensitizing hydrogel with tumour-confined stability for intrinsically targeted sonodynamic therapy.

Biomaterials·2026
Same journal

Multidimensional intestinal barrier repair strategies for alleviating inflammatory bowel disease and gut-liver axis-associated metabolic liver disease.

Biomaterials·2026
Same journal

A dual-twisted molecular strategy achieves dramatic quantum-yield enhancement in NIR-II AIEgen for high-performance bioimaging.

Biomaterials·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Multimeric peptide-based PEG nanocarriers with programmable elimination properties.

Simi Gunaseelan1, Shahriar Pooyan, Peiming Chen

  • 1Department of Pharmaceutics, Rutgers University, NJ 08854, USA.

Biomaterials
|August 4, 2009
PubMed
Summary
This summary is machine-generated.

Researchers designed biodegradable, PEG-based nanocarriers for controlled drug delivery. These nanocarriers selectively degrade inside cells, facilitating predictable elimination pathways and enhancing therapeutic safety.

More Related Videos

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
06:57

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Related Experiment Videos

Last Updated: Jun 21, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
06:57

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery

Background:

  • Peptide-based nanocarriers offer tunable properties for biomedical applications.
  • Polyethylene glycol (PEG)ylation is crucial for improving nanocarrier stability and circulation time.
  • Biodegradable nanocarriers are essential for safe and effective drug delivery systems.

Purpose of the Study:

  • To design and synthesize novel biodegradable peptidic PEG-based nanocarriers.
  • To investigate the influence of nanocarrier components on biodegradation and body elimination pathways.
  • To optimize synthesis conditions for improved yield and reduced polydispersity.

Main Methods:

  • Synthesis of non-PEGylated and PEGylated peptidic cores.
  • Preparation of homodimeric and heterodimeric nanocarriers using disulfide bonds.
  • Optimization of coupling reactions using beta-alanine spacers and DMSO.
  • Evaluation of nanocarrier stability and biodegradation in simulated intracellular and extracellular environments.

Main Results:

  • Significantly higher yields (69% vs. 30%) achieved for PEGylated peptidic cores using beta-alanine spacers and increased DMSO.
  • Stoichiometric addition of components crucial for reducing nanocarrier polydispersity.
  • Nanocarriers demonstrated 9-fold greater stability in extracellular environments compared to intracellular conditions.
  • Selective intracellular degradation observed, yielding components with known elimination pathways.

Conclusions:

  • Developed biodegradable peptidic PEG-based nanocarriers with tunable properties.
  • Demonstrated selective intracellular degradation, enabling predictable body elimination.
  • Optimized synthesis conditions for efficient and reproducible nanocarrier production.